OP Labs formerly Oxford PeptidesBatch HPLC tested at 99% purityStore frozen long term or in fridge when ready to be usedSold for research purposes onlyContact us for Wholesale OrdersLL-37Synonyms / Designations: LL-37, CAP-18 (C-terminal fragment), Human Cathelicidin Antimicrobial PeptideCAS Number: 154947-66-7Molecular Formula: C205H340N60O53Molecular Weight: 4493.33 g/molPurity: ≥ 98 % (HPLC)Appearance: White to off-white lyophilised powderPack Size: 5 mg (total)Storage: Desiccated, protected from light, stored at −20 °C or belowSolubility: Soluble in water and buffered aqueous solutionsDescription & MechanismLL-37 is a 37-amino acid peptide derived from the C-terminal domain of human cathelicidin (hCAP-18). It is the only cathelicidin-derived antimicrobial peptide identified in humans and is widely used as a research tool for investigating innate immune defence mechanisms in experimental systems.In biochemical and cellular research models, LL-37 has been reported to interact with bacterial membranes and modulate host immune signalling pathways. Observed activities include membrane disruption in microbial models, modulation of inflammatory mediator release, and influence on cell migration and proliferation in in vitro assays. Experimental outcomes are highly dependent on concentration, model system, and assay conditions.Applications in ResearchAs a molecular tool to study host-defence peptide activity and innate immune signallingInvestigation of antimicrobial peptide–membrane interactions in microbial model systemsIn vitro studies examining immunomodulatory effects on cytokine and chemokine releasePreclinical or ex vivo experimental models for mechanistic investigation of cathelicidin biologySpecifications SummaryParameterTypical Value / RangePurity (HPLC)≥ 98AppearanceWhite to off-white lyophilised powderMolecular Weight4493.33 g/molPeptide TypeSynthetic cathelicidin-derived antimicrobial peptideSolubilityWater, buffered aqueous solutionsStorage−20 °C, desiccated, darkPack Size5 mgHandling, Reconstitution & StabilityWeigh under dry conditions; peptide is hygroscopicReconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirementsAvoid vigorous agitation during dissolutionFilter sterilize if required (e.g. 0.22 μm) prior to useAliquot and store reconstituted solutions at −20 °C or below to minimise degradationAvoid repeated freeze–thaw cyclesPrecautions & NotesExperimental behaviour of LL-37 is dependent on concentration, model system, and exposure conditionsDue to reported interaction with multiple immune signalling pathways, appropriate experimental controls are recommendedProlonged exposure to light, elevated temperature, or aqueous environments may reduce stabilityIntended strictly for laboratory research use; not for human or veterinary applicationReferencesVandamme D. et al. A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cellular Immunology, 2012.https://pubmed.ncbi.nlm.nih.gov/22571893/Kahlenberg J.M. & Kaplan M.J. Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. The Journal of Immunology, 2013.https://pubmed.ncbi.nlm.nih.gov/24127553/
