OP Labs formerly Oxford PeptidesBatch HPLC tested at 99% purityStore frozen long term or in fridge when ready to be usedSold for research purposes onlyContact us for Wholesale OrdersDownload COA here: Cagrilintide_COA.pdfPlease note if you have a different Batch ID please contact us for the latest COA.CagrilintideSynonyms / Designations: Cagrilintide, AM833, Long-acting amylin analogue, Dual amylin receptor agonistCAS Number:1415456-99-3Molecular Formula: C194H312N54O59S2Molecular Weight: 4409.01 g/molPeptide Classification: Synthetic long-acting amylin analoguePurity: ≥ 99 % (HPLC, typical)Appearance: White to off-white lyophilised powderPack Size: Research pack size (varies)Storage: Desiccated, protected from light, stored at –20 °CSolubility: Soluble in sterile water and buffered aqueous solutionsDescription & MechanismCagrilintide is a synthetic long-acting analogue of the endogenous peptide hormone amylin, developed for experimental investigation of amylin receptor signalling and metabolic regulation. Structural modifications to the native amylin sequence enhance stability and prolong systemic persistence in research models.In biochemical and cellular research systems, cagrilintide interacts with amylin receptors formed by calcitonin receptor complexes, activating downstream signalling pathways involved in appetite regulation, gastric emptying, and metabolic homeostasis. Experimental studies focus on receptor binding characteristics, signal transduction dynamics, and pathway modulation under controlled conditions. Observed molecular responses are dependent on experimental design, concentration, and model system, and are used to investigate peptide-mediated signalling rather than defined biological or clinical outcomes.Applications in ResearchAs a molecular probe for studying amylin receptor binding and activationInvestigation of appetite-regulating and metabolic signalling pathwaysIn vitro studies examining peptide stability and receptor selectivityUse as a reference compound in metabolic and peptide signalling researchHandling, Reconstitution & StabilityWeigh under dry conditions; peptide is hygroscopicReconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirementsAvoid vigorous agitation during dissolutionFilter sterilize if required (e.g. 0.22 µm) immediately prior to useAliquot and store reconstituted solutions at –20 °C (or lower) to minimise degradationAvoid repeated freeze–thaw cyclesSpecifications SummaryPurity (HPLC): ≥ 99 %Appearance: White to off-white lyophilised powderPeptide Type: Synthetic amylin analogueSolubility: Water, buffered aqueous solutionsStorage: –20 °C, desiccated, darkPrecautions & NotesExperimental behaviour of cagrilintide is influenced by receptor expression, concentration, and exposure durationAmylin analogues may exhibit signalling profiles distinct from native amylinBuffer composition, pH, and ionic strength may affect peptide stability and assay performanceAppropriate controls are recommended to distinguish specific from non-specific effectsIntended strictly for laboratory research use; not for human or veterinary applicationReferencesLarsen P.J. et al. Amylin receptor agonism and metabolic regulation. Diabetologia. PubMed abstract and citation:https://pubmed.ncbi.nlm.nih.gov/36242844/Gydesen S. et al. Cagrilintide, a long-acting amylin analogue: pharmacology and receptor activity. Diabetes, Obesity and Metabolism. PubMed abstract and citation:https://pubmed.ncbi.nlm.nih.gov/33502015/Hay D.L., Poyner D.R. Amylin and calcitonin receptor signalling mechanisms. British Journal of Pharmacology. PubMed abstract and review article:https://pubmed.ncbi.nlm.nih.gov/18466316/Novo Nordisk. Scientific communications and research information on AM833 (cagrilintide). Novo Nordisk Science Hub:https://sciencehub.novonordisk.com/search?query=cagrilintideKeywords: Cagrilintide, AM833, Amylin Analogue, Metabolic Peptide, Research Peptide
