OP Labs formerly Oxford PeptidesBatchHPLC tested at 99% purityStore frozen long term or in fridge when ready to be usedSold for research purposes onlyContact us for Wholesale OrdersDownload COA here: FOXO4_COA.pdfPlease note: if you have a different Batch ID, please contact us for the latest COA.FOXO4 Peptide (FOXO4-DRI)Synonyms: FOXO4-DRI, FOXO4 inhibitory peptide, FOXO4 decoy peptideCAS Number: N/APeptide Classification: Synthetic modified peptide; protein–protein interaction inhibitorMolecular Formula: C228H388N86O64Molecular Weight: 5358.05 g/molAppearance: White to off-white lyophilised powderPurity: ≥ 98 % (HPLC, typical)Solubility: Soluble in water and buffered aqueous solutionsStorage: –20 °C, desiccated, protected from lightPack Size: 10mgDescription & MechanismFOXO4-DRI is a synthetic, modified peptide derived from regions of the Forkhead box O4 (FOXO4) transcription factor. It was engineered using a D-retro-inverso design to improve stability and resistance to proteolytic degradation in experimental systems.In biochemical and cellular research models, FOXO4-DRI has been used to study protein–protein interactions between FOXO4 and p53. The peptide acts as a competitive inhibitor of this interaction, enabling investigation of transcriptional regulation, cellular senescence pathways, and stress-response signalling. Observed effects are dependent on experimental design, concentration, and model system, and are used for mechanistic exploration rather than defined biological outcomes.Applications in Research• Investigation of FOXO4–p53 protein–protein interactions• Study of cellular senescence and transcription factor regulation• In vitro models examining stress-response signalling pathways• Use as a research tool in aging and cell-cycle biology studiesHandling & Stability• Handle under dry, clean laboratory conditions• Reconstitute in sterile water or appropriate buffered solution• Avoid vigorous agitation during dissolution• Aliquot reconstituted solutions to avoid repeated freeze–thaw cycles• Store reconstituted material at –20 °C or below for long-term stabilitySpecifications SummaryPurity: ≥ 98 % (HPLC)Appearance: White to off-white lyophilised powderPeptide Type: Synthetic modified research peptideMolecular Weight: 5358.05 g/molSolubility: Water, buffered aqueous solutionsStorage: –20 °C, desiccated, protected from lightPrecautions & Notes• Intended strictly for laboratory research use• Not for human or veterinary application• Experimental outcomes may vary depending on model system and assay design• Appropriate controls are recommended to interpret pathway-specific effectsReferencesBaar M.P. et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell, 2017.https://pubmed.ncbi.nlm.nih.gov/28340339/van Deursen J.M. The role of senescent cells in ageing. Nature, 2014.https://pmc.ncbi.nlm.nih.gov/articles/PMC4214092/Calnan D.R., Brunet A. The FoxO code. Oncogene, 2008.https://pubmed.ncbi.nlm.nih.gov/18391970/Keywords: FOXO4, FOXO4-DRI, FOXO4 peptide, senescence research peptide, p53 interaction inhibitor
