OP Labs formerly Oxford PeptidesBatch HPLC tested at 99% purityStore frozen long term or in fridge when ready to be usedSold for research purposes onlyContact us for Wholesale OrdersDownload COA here: IGF1_LR3_COA.pdfPlease note: if you have a different Batch ID, please contact us for the latest COA.IGF-1 LR3Synonyms / Designations: IGF-1 LR3, Long Arg³ IGF-1, Insulin-Like Growth Factor-1 LR3, Recombinant IGF-1 analogueCAS Number: 946870-92-4Molecular Formula: C400H625N111O115S9Molecular Weight: 9117.5 g/molPeptide Classification: Synthetic analogue of insulin-like growth factor-1 (IGF-1)Purity: ≥ 99 % (HPLC, typical)Appearance: White to off-white lyophilised powderPack Size: 1 mg (total)Storage: Desiccated, protected from light, stored at –20 °CSolubility: Soluble in sterile water and buffered aqueous solutionsDescription & MechanismIGF-1 LR3 is a synthetic analogue of human insulin-like growth factor-1 (IGF-1) incorporating an arginine substitution at position 3 and an extended N-terminal sequence. These structural modifications reduce affinity for endogenous IGF binding proteins, resulting in altered stability and interaction characteristics in experimental systems compared to native IGF-1.In biochemical and cellular research models, IGF-1 LR3 interacts with the IGF-1 receptor (IGF-1R), initiating intracellular signalling cascades associated with growth factor–mediated pathways. Research studies commonly examine receptor binding behaviour, downstream signalling kinetics, and comparative responses relative to native IGF-1. Observed molecular effects are dependent on experimental design, concentration, and model system and are used to investigate IGF-1 receptor signalling rather than defined biological or physiological outcomes.Applications in ResearchAs a molecular tool for studying IGF-1 receptor binding and activation dynamicsInvestigation of growth factor–mediated intracellular signalling pathwaysIn vitro studies comparing modified and native IGF-1 analoguesUse as a reference compound in endocrine and peptide signalling researchHandling, Reconstitution & StabilityWeigh under dry conditions; peptide is hygroscopicReconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirementsAvoid vigorous agitation during dissolutionFilter sterilize if required (e.g. 0.22 µm) immediately prior to useAliquot and store reconstituted solutions at –20 °C (or lower) to minimise degradationAvoid repeated freeze–thaw cyclesSpecifications SummaryParameterTypical Value / RangePurity (HPLC)≥ 99 %AppearanceWhite to off-white lyophilised powderMolecular Weight~9117.5 g/molPeptide TypeSynthetic IGF-1 analogueSolubilityWater, buffered aqueous solutionsStorage–20 °C, desiccated, darkPack Size1 mgPrecautions & NotesExperimental behaviour of IGF-1 LR3 is influenced by receptor expression, concentration, and exposure durationModified IGF-1 analogues may exhibit signalling profiles distinct from native IGF-1Buffer composition, pH, and ionic strength may affect peptide stability and assay performanceAppropriate controls are recommended to distinguish specific from non-specific effectsIntended strictly for laboratory research use; not for human or veterinary applicationReferencesFrancis G.L. et al. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. Journal of Molecular Endocrinology, 1992.https://pubmed.ncbi.nlm.nih.gov/1378742/Tomas F.M. et al. Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection. Journal of Endocrinology, 1996.https://pubmed.ncbi.nlm.nih.gov/8708565/Ballard F.J. et al. Does IGF-I ever act through the insulin receptor? Cytokine & Growth Factor Reviews, 1996.https://pubmed.ncbi.nlm.nih.gov/8899293/Keywords: IGF-1 LR3, Long Arg³ IGF-1, Insulin-Like Growth Factor Analogue, Synthetic Growth Factor
