OP Labs formerly Oxford PeptidesBatch HPLC tested at 99% purityStore frozen long term or in fridge when ready to be usedSold for research purposes onlyContact us for Wholesale OrdersDownload COA here: Epithalon_COA.pdfPlease note: if you have a different Batch ID, please contact us for the latest COA.EpithalonSynonyms / Designations: Epithalon, Epitalon, Ala–Glu–Asp–Gly, Epithalamin-derived tetrapeptideCAS Number: 307297-39-8Molecular Formula: C14H22N4O9Molecular Weight: 390.35 g/molPeptide Sequence: Ala–Glu–Asp–GlyPeptide Classification: Synthetic tetrapeptide; epithalamin-derived analoguePurity: ≥ 99 % (HPLC, typical)Appearance: White to off-white lyophilised powderPack Size: 10 mg (total)Storage: Desiccated, protected from light, stored at –20 °CSolubility: Soluble in water and buffered aqueous solutionsDescription & MechanismEpithalon is a synthetic tetrapeptide corresponding to a defined amino acid sequence originally identified as an active fragment of epithalamin, a peptide preparation derived from pineal tissue in early experimental studies. It was developed to provide a chemically well-characterised molecule suitable for controlled investigation of short peptide signalling in cellular and molecular research systems.In biochemical and cellular research models, Epithalon has been examined for its interactions with nuclear and chromatin-associated processes, including modulation of gene expression and telomere-related regulatory mechanisms. Experimental studies have investigated its influence on chromatin structure, telomerase-associated activity, and intracellular signalling pathways, with observed effects dependent on concentration, exposure duration, and model system. Epithalon is used as a molecular research tool to explore peptide-mediated regulation rather than defined biological or clinical outcomes.Applications in ResearchAs a molecular probe for studying short peptide–mediated intracellular signallingInvestigation of chromatin organisation, gene expression regulation, and telomere-associated processes in cell modelsIn vitro studies examining peptide–nucleus interactions and regulatory pathwaysAs a reference compound in research involving pineal-derived peptide fragmentsHandling, Reconstitution & StabilityWeigh under dry conditions; peptide is hygroscopicReconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirementsAvoid vigorous agitation during dissolutionFilter sterilize if required (e.g. 0.22 µm) immediately prior to useAliquot and store reconstituted solutions at –20 °C (or lower) to minimise degradationAvoid repeated freeze–thaw cycles.Specifications SummaryParameterTypical Value / RangePurity (HPLC)≥ 99 %AppearanceWhite to off-white lyophilised powderMolecular Weight390.35 g/molPeptide TypeSynthetic tetrapeptideSolubilityWater, buffered aqueous solutionsStorage–20 °C, desiccated, darkPack Size5 mgPrecautions & NotesExperimental behaviour of Epithalon is dependent on concentration, exposure duration, and experimental modelBuffer composition, pH, and ionic strength may influence peptide stability and assay performanceLiterature reports are derived from heterogeneous experimental systems and should be interpreted accordinglyAppropriate controls are recommended to distinguish specific from non-specific effectsIntended strictly for laboratory research use; not for human or veterinary applicationReferencesKhavinson V.Kh. et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine, 2003.https://pubmed.ncbi.nlm.nih.gov/12937682/Anisimov V.N. et al. Epitalon increases telomere length in somatic cells. Advances in Gerontology, 2024.https://pmc.ncbi.nlm.nih.gov/articles/PMC12411320/Overview of Epitalon peptide research and mechanisms.https://pmc.ncbi.nlm.nih.gov/articles/PMC11943447/Keywords: Epithalon, Epitalon, Synthetic Tetrapeptide, Pineal Peptide Analogue
